How Our ADME and Toxicity Services Can Help You ?
The pharmaceutical industry has been evolving in recent years, which made numerous CROs and biotech companies conducting drug discovery and development programs and services worldwide. In the Computer aided drug discovery processes. We as Contact research organisation, provides ADME and Toxicity Services, which plays a crucial and vital role because these properties account for the failure of about 60% of all drugs in the clinical phases. In our ADME and Toxicity Services, we follow early in vitro which provides ADME screening basis for choosing new molecular entities (NMEs) and lead compounds that have desirable drug metabolism (drug screening), necessary for drug candidate selection (CS) and late‐stage preclinical and clinical development).
In contrast, to perform ADME analysis, traditionally ADME tests/tools were applied at the end of the drug development pipeline. Presently, ADME is applied at an early phase of the drug development process and that’s what our ADME and Toxicity Services d. Our ADME and Toxicity Services screen molecules with poor ADME properties from the drug development pipeline and leads to significant savings in research and development costs. ADME and Toxicity Services or DMPK, is an important part of studies often referred to as ADME (Absorption, Distribution, Metabolism, and Elimination
Also, as a very comprehensive and important technology platform in drug discovery bridging efficacy and safety, the ADME and Toxicity Services or DMPK studies or Drug Metabolism and Pharmacokinetics or ADME assay has become a mature discovery function to optimize ADME properties in drug design and screening, and dramatically mitigate attrition rates during the last decades.
Key Areas Of ADME and Toxicity Analysis Services
ADMET (Absorption, Distribution, Metabolism, Elimination and Toxicology).
– Absorption (how much and how fast, often referred to as the absorbed fraction or bioavailability);
– Distribution (where the drug is distributed, how fast and how extensive);
– Metabolism (how fast, what mechanism/route, what metabolite is formed, and whether they are active or toxic);
– Elimination (how fast, which route).
– Toxicity studies are done to determine the dose level recommended for the treatment of disease as drug. With the guide lines that enable the characterization of adverse effects following repeated daily inhalation exposure to a test.
The ADME properties of a drug allow the drug developer to understand the safety and efficacy data required for regulatory approval
Our Publications
We have wide range of research publications which showcases the work we have carried out for different clients and our in-house R&D in the past few years.
Our Case Studies
Our service solutions apply to different purposes such as molecular medicine,microbial genome application,agriculture, animal,comparative studies,discoveries etc.
100% Post Service Assistance
We at RASA connect with our clients not only pre service or during service but also,after the service is delivered.
Data security
We assured highly secured data management and work environment.
Quality assurance
Our service aims at perfection and we deliver what is promised. We assure for quality assured services.
Experienced Team
Experienced portfolio management capabilities.
Service Customization
Apart from the package of services provided by us, we also customize service for our clients.
Free Services Training
We not only aim at delivering services but also provide onsite training on the services to the respective clients.
Our Achievements
Our ADME and Toxicity Services Workflow
-
1.
Brainstorming
Communicate your requirements along with your data and we will start working on the service. -
2.
Design
To finalize the steps required to successfully execute the service. -
3.
Service Execution
Start to work on the service keeping in mind the design & the data. -
4.
Result Evaluation
Generating results from the service & discussing the same so that client understand it thoroughly.
Clients' Testimonial
Meet Our Team
Sapana Mehendale
Sameer Chaudhary
Esha Biswas
Sakshi Rawat
Gouri Ahir
Punnag Ghaisas
Our Key Areas Of Life Science's Services
Bioinformatics Consultancy Services
RASA experts help you to model 3D protein structures & identify opportunities to streamline your research with genomics & proteomic data analysis.
Next Generation Sequencing Data Analysis Services
RASA experts help you to manage, organize,analyze your any type of genomic data by using gold standard Next generation sequencing data analysis i.e NGS Data Analysis methods.
Computational Drug Discovery Services
RASA prowess in computational chemistry, structural biology, molecular modelling, simulation.
Customised Services
We at RASA understand that the research you do is innovative and novel. Innovative research needs innovative solutions.We do provide customization in our services according to your research requirement.