De novo assembly or sequencing refers to sequencing a novel genome where there is no reference sequence available for alignment. Sequence reads are assembled as contigs, and the coverage quality of de novo sequence data depends on the size and continuity of the contigs (ie, the number of gaps in the data). Next-generation sequencing (NGS) enables faster, more accurate characterization of any species compared to traditional methods, such as Sanger sequencing. Hence, genome assembly refers to the process of taking a large number of short DNA sequences and putting them back together to create a representation of the original chromosomes from which the DNA originated. Wherein, de novo genome assemblies assume no prior knowledge of the source DNA sequence length, layout or composition. In a genome sequencing project, the DNA of the target organism is broken up into millions of small pieces and read on a sequencing machine. These “reads” vary from 20 to 1000 nucleotide base pairs (bp) in length depending on the sequencing method used. RASA Bioinformatic Lab’s  genome annotation services can provide you a closer view on the de novo assembly and genome data analysis and furthermore providing de-novo based RNA-Sequence Data Analysis services for the obtained data.

Among the main goals of the Human Genome Project (HGP) was to develop new, better and cheaper tools to identify new genes and to understand their function. One of these tools is gene mapping. Genemapping also called linkage mapping can offer firm evidence that a disease transmitted from parent to child is linked to one or more genes. Gene Mapping also provides clues about which chromosome contains the gene and precisely where the gene lies on that chromosome.

Genetic maps are also useful in guiding scientists to the many genes that are believed to play a role in the development of more common disorders such as asthma, heart disease, diabetes, cancer, and psychiatric conditions. Identification of genes is usually the first step in understanding a genome of a species; mapping of the gene is usually the first step of identification of the gene. Gene mapping is usually the starting point of many important downstream studies. Hence we at RASA Bioinformatic CRO Lab’s genome annotation services can also perform gene mapping annotation to discover genes responsible for a disease or disorder or just to get data sufficient enough as the genetic counselling requirements, etc.